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Cannibalization of pups increased in a dose-related manner; this effect zopiclone might have been due to the fact that the pups were sedated, hypothermic and had problems with suckling .
Gross behaviour, physical development, auditory function, spontaneous motor activity and learning behaviour zopiclone were normal in the surviving F1 pups .
Males and females from the F1 generation mated successfully except for three rats which were zopiclone infertile (one male rat from the 50 mg/kg group and one male and one female rat from the 250 mg/kg group) .
The male rat from the mid dose group had bilateral hypoplastic testes and zopiclone epididymis .
Mortality and weights of the F2 generation zopiclone were within the normal range for the strain used .
One F2 pup, from the mid dose group, had oligodactyly with syndactyly of the left zopiclone forelimb .
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