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Metabolism and Excretion: Mostly metabolized on first pass through the liver (by CYP1A2, CYP2D6, and CYP3A4 isoenzymes); (the CYP2D6 enzyme system exhibits genetic polymorphism; ⬃7% of population may be poor metabolizers clozaril and may have significantlyqclozapine concentrations and anqrisk of adverse effects) .
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Plate # 0-Composite Contraindications/Precautions Contraindicated in: Hypersensitivity; Bone marrow depression; Severe CNS depression/coma; Uncontrolled epilepsy; Clozapine-induced agranulocytosis or severe granulocytopenia; Lactation: Discontinue drug clozaril helpline clozaril lawsuit clozaril database clozaril also known as clozaril health teaching or bottle-feed .

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