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The observed potency of phentermine for inhibiting the serotonin-metabolizing MAO-A in rat liver, lung, and brain was much greater than that previously reported: The early studies concluded that phentermine inhibits adipex reviews bad phentermine 30 mg en espanol efectos secundarios adipex hcl 30mg yellow adipex MAO with EC50 values of 10 mM or 270 M for rat liver [15] or brain [14], respectively .
These EC50 values were clearly different from, and side effects of phentermine adipex weight loss first week adipex 37.5 not working anymore much higher than, the Ki values (and apparent EC50 values) observed in the present study .
In these previous studies, however, the concentrations of serotonin used as a adipex MAO substrate (5 or 2 mM) were several-fold higher than its concentration (125 M) used in the present study .
Clearly, the potency of phentermine was underestimated in adipex the previous studies .
Phentermine was second adipex only to d-amphetamine, among the unlabeled MAO inhibitors tested in the present study, for its ability to inhibit MAO-A as well as MAO-B .
The potencies of phentermine, d-amphetamine, and related drugs for inhibiting adipex the serotonin-metabolizing MAO-A I .
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